| Week 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | |||||
| Week 1 | |||||
| Date | Game | Score | Time | ||
|---|---|---|---|---|---|
| 2008-09-04 | Washington Redskins | at | New York Giants | 7 - 16 | Thu 7:00pm EST |
| 2008-09-07 | New York Jets | at | Miami Dolphins | 20 - 14 | Sun 1:00pm EST |
| 2008-09-07 | St. Louis Rams | at | Philadelphia Eagles | 3 - 38 | Sun 1:00pm EST |
| 2008-09-07 | Houston Texans | at | Pittsburgh Steelers | 17 - 38 | Sun 1:00pm EST |
| 2008-09-07 | Kansas City Chiefs | at | New England Patriots | 10 - 17 | Sun 1:00pm EST |
| 2008-09-07 | Cincinnati Bengals | at | Baltimore Ravens | 10 - 17 | Sun 1:00pm EST |
| 2008-09-07 | Seattle Seahawks | at | Buffalo Bills | 10 - 34 | Sun 1:00pm EST |
| 2008-09-07 | Jacksonville Jaguars | at | Tennessee Titans | 10 - 17 | Sun 1:00pm EST |
| 2008-09-07 | Detroit Lions | at | Atlanta Falcons | 21 - 34 | Sun 1:00pm EST |
| 2008-09-07 | Tampa Bay Bucs | at | New Orleans Saints | 20 - 24 | Sun 1:00pm EST |
| 2008-09-07 | Arizona Cardinals | at | San Francisco 49ers | 23 - 13 | Sun 4:15pm EST |
| 2008-09-07 | Dallas Cowboys | at | Cleveland Browns | 28 - 10 | Sun 4:15pm EST |
| 2008-09-07 | Carolina Panthers | at | San Diego Chargers | 26 - 24 | Sun 4:15pm EST |
| 2008-09-07 | Chicago Bears | at | Indianapolis Colts | 29 - 13 | Sun 8:15pm EST |
| 2008-09-08 | Minnesota Vikings | at | Green Bay Packers | 19 - 24 | Mon 7:00pm EST |
| 2008-09-08 | Denver Broncos | at | Oakland Raiders | 41 - 14 | Mon 10:15pm EST |
| Week 2 | |||||
| Date | Game | Score | Time | ||
| 2008-09-14 | Oakland Raiders | at | Kansas City Chiefs | 23 - 8 | Sun 1:00pm EST |
| 2008-09-14 | Indianapolis Colts | at | Minnesota Vikings | 18 - 15 | Sun 1:00pm EST |
| 2008-09-14 | Buffalo Bills | at | Jacksonville Jaguars | 20 - 16 | Sun 1:00pm EST |
| 2008-09-14 | Green Bay Packers | at | Detroit Lions | 48 - 25 | Sun 1:00pm EST |
| 2008-09-14 | Tennessee Titans | at | Cincinnati Bengals | 24 - 7 | Sun 1:00pm EST |
| 2008-09-14 | Chicago Bears | at | Carolina Panthers | 17 - 20 | Sun 1:00pm EST |
| 2008-09-14 | New Orleans Saints | at | Washington Redskins | 24 - 29 | Sun 1:00pm EST |
| 2008-09-14 | New York Giants | at | St. Louis Rams | 41 - 13 | Sun 1:00pm EST |
| 2008-09-14 | Atlanta Falcons | at | Tampa Bay Bucs | 9 - 24 | Sun 4:05pm EST |
| 2008-09-14 | San Francisco 49ers | at | Seattle Seahawks | 33 - 30 | Sun 4:05pm EST |
| 2008-09-14 | Miami Dolphins | at | Arizona Cardinals | 10 - 31 | Sun 4:15pm EST |
| 2008-09-14 | San Diego Chargers | at | Denver Broncos | 38 - 39 | Sun 4:15pm EST |
| 2008-09-14 | New England Patriots | at | New York Jets | 19 - 10 | Sun 4:15pm EST |
| 2008-09-14 | Pittsburgh Steelers | at | Cleveland Browns | 10 - 6 | Sun 8:15pm EST |
| 2008-09-15 | Philadelphia Eagles | at | Dallas Cowboys | 37 - 41 | Mon 8:30pm EST |
| Houston Texans on BYE | |||||
| Baltimore Ravens on BYE | |||||
| Week 3 | |||||
| Date | Game | Score | Time | ||
| 2008-09-21 | Miami Dolphins | at | New England Patriots | 38 - 13 | Sun 1:00pm EST |
| 2008-09-21 | Houston Texans | at | Tennessee Titans | 12 - 31 | Sun 1:00pm EST |
| 2008-09-21 | Cincinnati Bengals | at | New York Giants | 23 - 26 | Sun 1:00pm EST |
| 2008-09-21 | Carolina Panthers | at | Minnesota Vikings | 10 - 20 | Sun 1:00pm EST |
| 2008-09-21 | Oakland Raiders | at | Buffalo Bills | 23 - 24 | Sun 1:00pm EST |
| 2008-09-21 | Tampa Bay Bucs | at | Chicago Bears | 27 - 24 | Sun 1:00pm EST |
| 2008-09-21 | Kansas City Chiefs | at | Atlanta Falcons | 14 - 38 | Sun 1:00pm EST |
| 2008-09-21 | Arizona Cardinals | at | Washington Redskins | 17 - 24 | Sun 1:00pm EST |
| 2008-09-21 | St. Louis Rams | at | Seattle Seahawks | 13 - 37 | Sun 4:05pm EST |
| 2008-09-21 | Detroit Lions | at | San Francisco 49ers | 13 - 31 | Sun 4:05pm EST |
| 2008-09-21 | New Orleans Saints | at | Denver Broncos | 32 - 34 | Sun 4:05pm EST |
| 2008-09-21 | Cleveland Browns | at | Baltimore Ravens | 10 - 28 | Sun 4:15pm EST |
| 2008-09-21 | Jacksonville Jaguars | at | Indianapolis Colts | 23 - 21 | Sun 4:15pm EST |
| 2008-09-21 | Pittsburgh Steelers | at | Philadelphia Eagles | 6 - 15 | Sun 4:15pm EST |
| 2008-09-21 | Dallas Cowboys | at | Green Bay Packers | 27 - 16 | Sun 8:15pm EST |
| 2008-09-22 | New York Jets | at | San Diego Chargers | 29 - 48 | Mon 8:30pm EST |
| Week 4 | |||||
| Date | Game | Score | Time | ||
| 2008-09-28 | San Francisco 49ers | at | New Orleans Saints | 17 - 31 | Sun 1:00pm EST |
| 2008-09-28 | Arizona Cardinals | at | New York Jets | 35 - 56 | Sun 1:00pm EST |
| 2008-09-28 | Atlanta Falcons | at | Carolina Panthers | 9 - 24 | Sun 1:00pm EST |
| 2008-09-28 | Cleveland Browns | at | Cincinnati Bengals | 20 - 12 | Sun 1:00pm EST |
| 2008-09-28 | Denver Broncos | at | Kansas City Chiefs | 19 - 33 | Sun 1:00pm EST |
| 2008-09-28 | Green Bay Packers | at | Tampa Bay Bucs | 21 - 30 | Sun 1:00pm EST |
| 2008-09-28 | Houston Texans | at | Jacksonville Jaguars | 27 - 30 | Sun 1:00pm EST |
| 2008-09-28 | Minnesota Vikings | at | Tennessee Titans | 17 - 30 | Sun 1:00pm EST |
| 2008-09-28 | Buffalo Bills | at | St. Louis Rams | 31 - 14 | Sun 4:05pm EST |
| 2008-09-28 | San Diego Chargers | at | Oakland Raiders | 28 - 18 | Sun 4:05pm EST |
| 2008-09-28 | Washington Redskins | at | Dallas Cowboys | 26 - 24 | Sun 4:15pm EST |
| 2008-09-28 | Philadelphia Eagles | at | Chicago Bears | 20 - 24 | Sun 8:15pm EST |
| 2008-09-29 | Baltimore Ravens | at | Pittsburgh Steelers | 20 - 23 | Mon 8:30pm EST |
| Seattle Seahawks on BYE | |||||
| Indianapolis Colts on BYE | |||||
| New England Patriots on BYE | |||||
| Miami Dolphins on BYE | |||||
| Detroit Lions on BYE | |||||
| Week 5 | |||||
| Date | Game | Score | Time | ||
| 2008-10-05 | Atlanta Falcons | at | Green Bay Packers | 27 - 24 | Sun 1:00pm EST |
| 2008-10-05 | Tennessee Titans | at | Baltimore Ravens | 13 - 10 | Sun 1:00pm EST |
| 2008-10-05 | San Diego Chargers | at | Miami Dolphins | 10 - 17 | Sun 1:00pm EST |
| 2008-10-05 | Seattle Seahawks | at | New York Giants | 6 - 44 | Sun 1:00pm EST |
| 2008-10-05 | Washington Redskins | at | Philadelphia Eagles | 23 - 17 | Sun 1:00pm EST |
| 2008-10-05 | Kansas City Chiefs | at | Carolina Panthers | 0 - 34 | Sun 1:00pm EST |
| 2008-10-05 | Indianapolis Colts | at | Houston Texans | 31 - 27 | Sun 1:00pm EST |
| 2008-10-05 | Chicago Bears | at | Detroit Lions | 34 - 7 | Sun 1:00pm EST |
| 2008-10-05 | Tampa Bay Bucs | at | Denver Broncos | 13 - 16 | Sun 4:05pm EST |
| 2008-10-05 | Buffalo Bills | at | Arizona Cardinals | 17 - 41 | Sun 4:15pm EST |
| 2008-10-05 | Cincinnati Bengals | at | Dallas Cowboys | 22 - 31 | Sun 4:15pm EST |
| 2008-10-05 | New England Patriots | at | San Francisco 49ers | 30 - 21 | Sun 4:15pm EST |
| 2008-10-05 | Pittsburgh Steelers | at | Jacksonville Jaguars | 26 - 21 | Sun 8:15pm EST |
| 2008-10-06 | Minnesota Vikings | at | New Orleans Saints | 30 - 27 | Mon 8:30pm EST |
| Cleveland Browns on BYE | |||||
| Oakland Raiders on BYE | |||||
| New York Jets on BYE | |||||
| St. Louis Rams on BYE | |||||
| Week 6 | |||||
| Date | Game | Score | Time | ||
| 2008-10-12 | Miami Dolphins | at | Houston Texans | 28 - 29 | Sun 1:00pm EST |
| 2008-10-12 | Chicago Bears | at | Atlanta Falcons | 20 - 22 | Sun 1:00pm EST |
| 2008-10-12 | St. Louis Rams | at | Washington Redskins | 19 - 17 | Sun 1:00pm EST |
| 2008-10-12 | Baltimore Ravens | at | Indianapolis Colts | 3 - 31 | Sun 1:00pm EST |
| 2008-10-12 | Carolina Panthers | at | Tampa Bay Bucs | 3 - 27 | Sun 1:00pm EST |
| 2008-10-12 | Oakland Raiders | at | New Orleans Saints | 3 - 34 | Sun 1:00pm EST |
| 2008-10-12 | Detroit Lions | at | Minnesota Vikings | 10 - 12 | Sun 1:00pm EST |
| 2008-10-12 | Cincinnati Bengals | at | New York Jets | 14 - 26 | Sun 1:00pm EST |
| 2008-10-12 | Jacksonville Jaguars | at | Denver Broncos | 24 - 17 | Sun 4:05pm EST |
| 2008-10-12 | Philadelphia Eagles | at | San Francisco 49ers | 40 - 26 | Sun 4:15pm EST |
| 2008-10-12 | Dallas Cowboys | at | Arizona Cardinals | 24 - 30 | Sun 4:15pm EST |
| 2008-10-12 | Green Bay Packers | at | Seattle Seahawks | 27 - 17 | Sun 4:15pm EST |
| 2008-10-12 | New England Patriots | at | San Diego Chargers | 10 - 30 | Sun 8:15pm EST |
| 2008-10-13 | New York Giants | at | Cleveland Browns | 14 - 35 | Mon 8:30pm EST |
| Kansas City Chiefs on BYE | |||||
| Buffalo Bills on BYE | |||||
| Week 7 | |||||
| Date | Game | Score | Time | ||
| 2008-10-19 | San Diego Chargers | at | Buffalo Bills | 14 - 23 | Sun 1:00pm EST |
| 2008-10-19 | San Francisco 49ers | at | New York Giants | 17 - 29 | Sun 1:00pm EST |
| 2008-10-19 | Tennessee Titans | at | Kansas City Chiefs | 34 - 10 | Sun 1:00pm EST |
| 2008-10-19 | Dallas Cowboys | at | St. Louis Rams | 14 - 34 | Sun 1:00pm EST |
| 2008-10-19 | Baltimore Ravens | at | Miami Dolphins | 27 - 13 | Sun 1:00pm EST |
| 2008-10-19 | Minnesota Vikings | at | Chicago Bears | 41 - 48 | Sun 1:00pm EST |
| 2008-10-19 | New Orleans Saints | at | Carolina Panthers | 7 - 30 | Sun 1:00pm EST |
| 2008-10-19 | Pittsburgh Steelers | at | Cincinnati Bengals | 38 - 10 | Sun 1:00pm EST |
| 2008-10-19 | Detroit Lions | at | Houston Texans | 21 - 28 | Sun 4:05pm EST |
| 2008-10-19 | Cleveland Browns | at | Washington Redskins | 11 - 14 | Sun 4:15pm EST |
| 2008-10-19 | New York Jets | at | Oakland Raiders | 13 - 16 | Sun 4:15pm EST |
| 2008-10-19 | Indianapolis Colts | at | Green Bay Packers | 14 - 34 | Sun 4:15pm EST |
| 2008-10-19 | Seattle Seahawks | at | Tampa Bay Bucs | 10 - 20 | Sun 8:15pm EST |
| 2008-10-20 | Denver Broncos | at | New England Patriots | 7 - 41 | Mon 8:30pm EST |
| Arizona Cardinals on BYE | |||||
| Atlanta Falcons on BYE | |||||
| Jacksonville Jaguars on BYE | |||||
| Philadelphia Eagles on BYE | |||||
| Week 8 | |||||
| Date | Game | Score | Time | ||
| 2008-10-26 | San Diego Chargers | at | New Orleans Saints | 32 - 37 | Sun 1:00pm EST |
| 2008-10-26 | Buffalo Bills | at | Miami Dolphins | 16 - 25 | Sun 1:00pm EST |
| 2008-10-26 | Oakland Raiders | at | Baltimore Ravens | 10 - 29 | Sun 1:00pm EST |
| 2008-10-26 | Atlanta Falcons | at | Philadelphia Eagles | 14 - 27 | Sun 1:00pm EST |
| 2008-10-26 | Arizona Cardinals | at | Carolina Panthers | 23 - 27 | Sun 1:00pm EST |
| 2008-10-26 | Washington Redskins | at | Detroit Lions | 25 - 17 | Sun 1:00pm EST |
| 2008-10-26 | Tampa Bay Bucs | at | Dallas Cowboys | 9 - 13 | Sun 1:00pm EST |
| 2008-10-26 | Kansas City Chiefs | at | New York Jets | 24 - 28 | Sun 1:00pm EST |
| 2008-10-26 | St. Louis Rams | at | New England Patriots | 16 - 23 | Sun 1:00pm EST |
| 2008-10-26 | Cincinnati Bengals | at | Houston Texans | 6 - 35 | Sun 4:05pm EST |
| 2008-10-26 | Cleveland Browns | at | Jacksonville Jaguars | 23 - 17 | Sun 4:05pm EST |
| 2008-10-26 | New York Giants | at | Pittsburgh Steelers | 21 - 14 | Sun 4:15pm EST |
| 2008-10-26 | Seattle Seahawks | at | San Francisco 49ers | 34 - 13 | Sun 4:15pm EST |
| 2008-10-27 | Indianapolis Colts | at | Tennessee Titans | 21 - 31 | Mon 8:30pm EST |
| Chicago Bears on BYE | |||||
| Denver Broncos on BYE | |||||
| Green Bay Packers on BYE | |||||
| Minnesota Vikings on BYE | |||||
| Week 9 | |||||
| Date | Game | Score | Time | ||
| 2008-11-02 | Green Bay Packers | at | Tennessee Titans | 16 - 19 | Sun 1:00pm EST |
| 2008-11-02 | Houston Texans | at | Minnesota Vikings | 21 - 28 | Sun 1:00pm EST |
| 2008-11-02 | Tampa Bay Bucs | at | Kansas City Chiefs | 30 - 27 | Sun 1:00pm EST |
| 2008-11-02 | Jacksonville Jaguars | at | Cincinnati Bengals | 19 - 21 | Sun 1:00pm EST |
| 2008-11-02 | Detroit Lions | at | Chicago Bears | 23 - 27 | Sun 1:00pm EST |
| 2008-11-02 | New York Jets | at | Buffalo Bills | 26 - 17 | Sun 1:00pm EST |
| 2008-11-02 | Baltimore Ravens | at | Cleveland Browns | 37 - 27 | Sun 1:00pm EST |
| 2008-11-02 | Arizona Cardinals | at | St. Louis Rams | 34 - 13 | Sun 1:00pm EST |
| 2008-11-02 | Miami Dolphins | at | Denver Broncos | 26 - 17 | Sun 4:05pm EST |
| 2008-11-02 | Dallas Cowboys | at | New York Giants | 14 - 35 | Sun 4:15pm EST |
| 2008-11-02 | Atlanta Falcons | at | Oakland Raiders | 24 - 0 | Sun 4:15pm EST |
| 2008-11-02 | Philadelphia Eagles | at | Seattle Seahawks | 26 - 7 | Sun 4:15pm EST |
| 2008-11-02 | New England Patriots | at | Indianapolis Colts | 15 - 18 | Sun 8:15pm EST |
| 2008-11-03 | Pittsburgh Steelers | at | Washington Redskins | 23 - 6 | Mon 8:30pm EST |
| San Francisco 49ers on BYE | |||||
| New Orleans Saints on BYE | |||||
| San Diego Chargers on BYE | |||||
| Week 10 | |||||
| Date | Game | Score | Time | ||
| 2008-11-06 | Denver Broncos | at | Cleveland Browns | 34 - 30 | Thu 8:15pm EST |
| 2008-11-09 | New Orleans Saints | at | Atlanta Falcons | 20 - 34 | Sun 1:00pm EST |
| 2008-11-09 | Tennessee Titans | at | Chicago Bears | 21 - 14 | Sun 1:00pm EST |
| 2008-11-09 | Jacksonville Jaguars | at | Detroit Lions | 38 - 14 | Sun 1:00pm EST |
| 2008-11-09 | Green Bay Packers | at | Minnesota Vikings | 27 - 28 | Sun 1:00pm EST |
| 2008-11-09 | Seattle Seahawks | at | Miami Dolphins | 19 - 21 | Sun 1:00pm EST |
| 2008-11-09 | St. Louis Rams | at | New York Jets | 3 - 47 | Sun 1:00pm EST |
| 2008-11-09 | Baltimore Ravens | at | Houston Texans | 41 - 13 | Sun 1:00pm EST |
| 2008-11-09 | Buffalo Bills | at | New England Patriots | 10 - 20 | Sun 1:00pm EST |
| 2008-11-09 | Carolina Panthers | at | Oakland Raiders | 17 - 6 | Sun 4:05pm EST |
| 2008-11-09 | Indianapolis Colts | at | Pittsburgh Steelers | 24 - 20 | Sun 4:15pm EST |
| 2008-11-09 | Kansas City Chiefs | at | San Diego Chargers | 19 - 20 | Sun 4:15pm EST |
| 2008-11-09 | New York Giants | at | Philadelphia Eagles | 36 - 31 | Sun 8:15pm EST |
| 2008-11-10 | San Francisco 49ers | at | Arizona Cardinals | 24 - 29 | Mon 8:30pm EST |
| Tampa Bay Bucs on BYE | |||||
| Dallas Cowboys on BYE | |||||
| Washington Redskins on BYE | |||||
| Cincinnati Bengals on BYE | |||||
| Week 11 | |||||
| Date | Game | Score | Time | ||
| 2008-11-13 | New York Jets | at | New England Patriots | 34 - 31 | Thu 8:15pm EST |
| 2008-11-16 | Chicago Bears | at | Green Bay Packers | 3 - 37 | Sun 1:00pm EST |
| 2008-11-16 | Denver Broncos | at | Atlanta Falcons | 24 - 20 | Sun 1:00pm EST |
| 2008-11-16 | Baltimore Ravens | at | New York Giants | 10 - 30 | Sun 1:00pm EST |
| 2008-11-16 | Minnesota Vikings | at | Tampa Bay Bucs | 13 - 19 | Sun 1:00pm EST |
| 2008-11-16 | Detroit Lions | at | Carolina Panthers | 22 - 31 | Sun 1:00pm EST |
| 2008-11-16 | Oakland Raiders | at | Miami Dolphins | 15 - 17 | Sun 1:00pm EST |
| 2008-11-16 | New Orleans Saints | at | Kansas City Chiefs | 30 - 20 | Sun 1:00pm EST |
| 2008-11-16 | Houston Texans | at | Indianapolis Colts | 27 - 33 | Sun 1:00pm EST |
| 2008-11-16 | Philadelphia Eagles | at | Cincinnati Bengals | 13 - 13 | Sun 1:00pm EST |
| 2008-11-16 | Arizona Cardinals | at | Seattle Seahawks | 26 - 20 | Sun 4:05pm EST |
| 2008-11-16 | St. Louis Rams | at | San Francisco 49ers | 16 - 35 | Sun 4:05pm EST |
| 2008-11-16 | Tennessee Titans | at | Jacksonville Jaguars | 24 - 14 | Sun 4:15pm EST |
| 2008-11-16 | San Diego Chargers | at | Pittsburgh Steelers | 10 - 11 | Sun 4:15pm EST |
| 2008-11-16 | Dallas Cowboys | at | Washington Redskins | 14 - 10 | Sun 8:15pm EST |
| 2008-11-17 | Cleveland Browns | at | Buffalo Bills | 29 - 27 | Mon 8:30pm EST |
| Week 12 | |||||
| Date | Game | Score | Time | ||
| 2008-11-20 | Cincinnati Bengals | at | Pittsburgh Steelers | 10 - 27 | Thu 8:15pm EST |
| 2008-11-23 | Houston Texans | at | Cleveland Browns | 16 - 6 | Sun 1:00pm EST |
| 2008-11-23 | Philadelphia Eagles | at | Baltimore Ravens | 7 - 36 | Sun 1:00pm EST |
| 2008-11-23 | Buffalo Bills | at | Kansas City Chiefs | 54 - 31 | Sun 1:00pm EST |
| 2008-11-23 | New York Jets | at | Tennessee Titans | 34 - 13 | Sun 1:00pm EST |
| 2008-11-23 | New England Patriots | at | Miami Dolphins | 48 - 28 | Sun 1:00pm EST |
| 2008-11-23 | Chicago Bears | at | St. Louis Rams | 27 - 3 | Sun 1:00pm EST |
| 2008-11-23 | Tampa Bay Bucs | at | Detroit Lions | 38 - 20 | Sun 1:00pm EST |
| 2008-11-23 | San Francisco 49ers | at | Dallas Cowboys | 22 - 35 | Sun 1:00pm EST |
| 2008-11-23 | Minnesota Vikings | at | Jacksonville Jaguars | 30 - 12 | Sun 1:00pm EST |
| 2008-11-23 | Oakland Raiders | at | Denver Broncos | 31 - 10 | Sun 4:05pm EST |
| 2008-11-23 | Carolina Panthers | at | Atlanta Falcons | 28 - 45 | Sun 4:15pm EST |
| 2008-11-23 | New York Giants | at | Arizona Cardinals | 37 - 29 | Sun 4:15pm EST |
| 2008-11-23 | Washington Redskins | at | Seattle Seahawks | 20 - 17 | Sun 4:15pm EST |
| 2008-11-23 | Indianapolis Colts | at | San Diego Chargers | 23 - 20 | Sun 8:15pm EST |
| 2008-11-24 | Green Bay Packers | at | New Orleans Saints | 29 - 51 | Mon 8:30pm EST |
| Week 13 | |||||
| Date | Game | Score | Time | ||
| 2008-11-27 | Tennessee Titans | at | Detroit Lions | 47 - 10 | Thu 12:30pm EST |
| 2008-11-27 | Seattle Seahawks | at | Dallas Cowboys | 9 - 34 | Thu 4:15pm EST |
| 2008-11-27 | Arizona Cardinals | at | Philadelphia Eagles | 20 - 48 | Thu 8:15pm EST |
| 2008-11-30 | New York Giants | at | Washington Redskins | 23 - 7 | Sun 1:00pm EST |
| 2008-11-30 | New Orleans Saints | at | Tampa Bay Bucs | 20 - 23 | Sun 1:00pm EST |
| 2008-11-30 | Miami Dolphins | at | St. Louis Rams | 16 - 12 | Sun 1:00pm EST |
| 2008-11-30 | Indianapolis Colts | at | Cleveland Browns | 10 - 6 | Sun 1:00pm EST |
| 2008-11-30 | Carolina Panthers | at | Green Bay Packers | 35 - 31 | Sun 1:00pm EST |
| 2008-11-30 | San Francisco 49ers | at | Buffalo Bills | 10 - 3 | Sun 1:00pm EST |
| 2008-11-30 | Baltimore Ravens | at | Cincinnati Bengals | 34 - 3 | Sun 1:00pm EST |
| 2008-11-30 | Atlanta Falcons | at | San Diego Chargers | 22 - 16 | Sun 4:05pm EST |
| 2008-11-30 | Denver Broncos | at | New York Jets | 34 - 17 | Sun 4:15pm EST |
| 2008-11-30 | Kansas City Chiefs | at | Oakland Raiders | 20 - 13 | Sun 4:15pm EST |
| 2008-11-30 | Pittsburgh Steelers | at | New England Patriots | 33 - 10 | Sun 4:15pm EST |
| 2008-11-30 | Chicago Bears | at | Minnesota Vikings | 14 - 34 | Sun 8:15pm EST |
| 2008-12-01 | Jacksonville Jaguars | at | Houston Texans | 17 - 30 | Mon 8:30pm EST |
| Week 14 | |||||
| Date | Game | Score | Time | ||
| 2008-12-04 | Oakland Raiders | at | San Diego Chargers | 7 - 34 | Thu 8:15pm EST |
| 2008-12-07 | Philadelphia Eagles | at | New York Giants | 20 - 14 | Sun 1:00pm EST |
| 2008-12-07 | Houston Texans | at | Green Bay Packers | 24 - 21 | Sun 1:00pm EST |
| 2008-12-07 | Minnesota Vikings | at | Detroit Lions | 20 - 16 | Sun 1:00pm EST |
| 2008-12-07 | Cleveland Browns | at | Tennessee Titans | 9 - 28 | Sun 1:00pm EST |
| 2008-12-07 | Jacksonville Jaguars | at | Chicago Bears | 10 - 23 | Sun 1:00pm EST |
| 2008-12-07 | Atlanta Falcons | at | New Orleans Saints | 25 - 29 | Sun 1:00pm EST |
| 2008-12-07 | Cincinnati Bengals | at | Indianapolis Colts | 3 - 35 | Sun 1:00pm EST |
| 2008-12-07 | Miami Dolphins | at | Buffalo Bills | 16 - 3 | Sun 4:05pm EST |
| 2008-12-07 | Kansas City Chiefs | at | Denver Broncos | 17 - 24 | Sun 4:05pm EST |
| 2008-12-07 | New England Patriots | at | Seattle Seahawks | 24 - 21 | Sun 4:05pm EST |
| 2008-12-07 | New York Jets | at | San Francisco 49ers | 14 - 24 | Sun 4:05pm EST |
| 2008-12-07 | St. Louis Rams | at | Arizona Cardinals | 10 - 34 | Sun 4:15pm EST |
| 2008-12-07 | Dallas Cowboys | at | Pittsburgh Steelers | 13 - 20 | Sun 4:15pm EST |
| 2008-12-07 | Washington Redskins | at | Baltimore Ravens | 10 - 24 | Sun 8:15pm EST |
| 2008-12-08 | Tampa Bay Bucs | at | Carolina Panthers | 23 - 38 | Mon 8:30pm EST |
| Week 15 | |||||
| Date | Game | Score | Time | ||
| 2008-12-11 | New Orleans Saints | at | Chicago Bears | 24 - 27 | Thu 8:15pm EST |
| 2008-12-14 | Tampa Bay Bucs | at | Atlanta Falcons | 10 - 13 | Sun 1:00pm EST |
| 2008-12-14 | Seattle Seahawks | at | St. Louis Rams | 23 - 20 | Sun 1:00pm EST |
| 2008-12-14 | San Francisco 49ers | at | Miami Dolphins | 9 - 14 | Sun 1:00pm EST |
| 2008-12-14 | San Diego Chargers | at | Kansas City Chiefs | 22 - 21 | Sun 1:00pm EST |
| 2008-12-14 | Tennessee Titans | at | Houston Texans | 12 - 13 | Sun 1:00pm EST |
| 2008-12-14 | Detroit Lions | at | Indianapolis Colts | 21 - 31 | Sun 1:00pm EST |
| 2008-12-14 | Washington Redskins | at | Cincinnati Bengals | 13 - 20 | Sun 1:00pm EST |
| 2008-12-14 | Buffalo Bills | at | New York Jets | 27 - 31 | Sun 1:00pm EST |
| 2008-12-14 | Green Bay Packers | at | Jacksonville Jaguars | 16 - 20 | Sun 1:00pm EST |
| 2008-12-14 | Minnesota Vikings | at | Arizona Cardinals | 35 - 14 | Sun 4:05pm EST |
| 2008-12-14 | Denver Broncos | at | Carolina Panthers | 10 - 30 | Sun 4:15pm EST |
| 2008-12-14 | New England Patriots | at | Oakland Raiders | 49 - 26 | Sun 4:15pm EST |
| 2008-12-14 | Pittsburgh Steelers | at | Baltimore Ravens | 13 - 9 | Sun 4:15pm EST |
| 2008-12-14 | New York Giants | at | Dallas Cowboys | 8 - 20 | Sun 8:15pm EST |
| 2008-12-15 | Cleveland Browns | at | Philadelphia Eagles | 10 - 30 | Mon 8:30pm EST |
| Week 16 | |||||
| Date | Game | Score | Time | ||
| 2008-12-18 | Indianapolis Colts | at | Jacksonville Jaguars | 31 - 24 | Thu 8:15pm EST |
| 2008-12-20 | Baltimore Ravens | at | Dallas Cowboys | 33 - 24 | Sat 8:15pm EST |
| 2008-12-21 | New Orleans Saints | at | Detroit Lions | 42 - 7 | Sun 1:00pm EST |
| 2008-12-21 | San Francisco 49ers | at | St. Louis Rams | 17 - 16 | Sun 1:00pm EST |
| 2008-12-21 | San Diego Chargers | at | Tampa Bay Bucs | 41 - 24 | Sun 1:00pm EST |
| 2008-12-21 | Pittsburgh Steelers | at | Tennessee Titans | 14 - 31 | Sun 1:00pm EST |
| 2008-12-21 | Cincinnati Bengals | at | Cleveland Browns | 14 - 0 | Sun 1:00pm EST |
| 2008-12-21 | Miami Dolphins | at | Kansas City Chiefs | 38 - 31 | Sun 1:00pm EST |
| 2008-12-21 | Arizona Cardinals | at | New England Patriots | 7 - 47 | Sun 1:00pm EST |
| 2008-12-21 | New York Jets | at | Seattle Seahawks | 3 - 13 | Sun 4:05pm EST |
| 2008-12-21 | Houston Texans | at | Oakland Raiders | 16 - 27 | Sun 4:05pm EST |
| 2008-12-21 | Buffalo Bills | at | Denver Broncos | 30 - 23 | Sun 4:05pm EST |
| 2008-12-21 | Atlanta Falcons | at | Minnesota Vikings | 24 - 17 | Sun 4:15pm EST |
| 2008-12-21 | Philadelphia Eagles | at | Washington Redskins | 3 - 10 | Sun 4:15pm EST |
| 2008-12-21 | Carolina Panthers | at | New York Giants | 28 - 34 | Sun 8:15pm EST |
| 2008-12-22 | Green Bay Packers | at | Chicago Bears | 17 - 20 | Mon 8:30pm EST |
| Week 17 | |||||
| Date | Game | Score | Time | ||
| 2008-12-28 | New York Giants | at | Minnesota Vikings | 19 - 20 | Sun 1:00pm EST |
| 2008-12-28 | Chicago Bears | at | Houston Texans | 24 - 31 | Sun 1:00pm EST |
| 2008-12-28 | Oakland Raiders | at | Tampa Bay Bucs | 31 - 24 | Sun 1:00pm EST |
| 2008-12-28 | Tennessee Titans | at | Indianapolis Colts | 0 - 23 | Sun 1:00pm EST |
| 2008-12-28 | Detroit Lions | at | Green Bay Packers | 21 - 31 | Sun 1:00pm EST |